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PBS Key take-aways Step-before-GLP-1 PBS now demands that an SGLT2-i be trialled (unless contraindicated) and either: caused intolerance, or failed to achieve 0.5 % (5 mmol/mol) HbA1c reduction after 6 months
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An alternative: Measuring urine levels of xanthurenic acid following intake of a high dose of tryptophan
10.1016/j.tibs.2017.11.004 261 SolimanH
(Source: illumina.com) November 2024: Ascendis Pharma licensed its TransCon technology to Novo Nordisk for metabolic and cardiovascular drug development, including a monthly GLP-1 agonist for obesity and diabetes
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